Our Approach to Orthobiologics and Regenerative Medicine

Orthobiologics is an emerging field in orthopedic surgery and sports medicine that utilizes natural substances derived from human cells and tissues to promote healing. At Stanford's academic center,one of the first academic orthobiologics clinics since 2011, our team of renowned researchers and clinicians are pioneering innovative orthobiologic therapies that harness the body's own healing mechanisms. These cutting-edge treatments, such as bone marrow cell, adipose tissue therapy, platelet-rich plasma (PRP) injections, and tissue engineering, are designed to effectively relieve discomfort from musculoskeletal injuries and degenerative conditions while avoiding traditional surgical interventions. By leveraging the power of the body's reparative cells and growth factors, orthobiologics offers promising solutions for conditions like osteoarthritis, tendon and ligament injuries, and cartilage defects, potentially reducing recovery times and improving long-term outcomes for our patients.

Our team is actively pursuing pioneering research in stem cell therapies and advanced tissue engineering techniques, with the goal of developing innovative regenerative treatments that can further improve healing and recovery for a wide range of orthopedic injuries and degenerative conditions.


William J. Maloney, MD
Department Chair of Orthopaedic Surgery


  • Multidisciplinary team of orthopaedic surgeons, sports medicine doctors, advanced practice providers, and physical therapists to advise each patient on the best treatment approach
  •  Leading-edge research to discover new and innovative ways to use orthobiologic treatments for all types of musculoskeletal injuries and conditions
  • Nationally and internationally recognized experts with highly specialized training and experience, leading the way in advancing the use of orthobiologic therapies for our patients
  • Expert second opinions on treatment options for sports injuries, including regenerative medicine

What Is Orthobiologics and Regenerative Medicine?

About Orthobiologics and Regenerative Medicine

Orthobiologics, a branch of regenerative medicine, encompasses the utilization of autologous or allogenic biological substances for the treatment of acute musculoskeletal injuries and chronic degenerative conditions affecting muscles, bones, joints, and soft tissues (ligaments, tendons, and cartilage). This innovative approach harnesses the body's innate healing mechanisms by leveraging cellular components derived from the patient's own tissues or donor sources.

The most commonly employed cellular and tissue sources in orthobiologic therapies include:

  • Adipose (fat) tissue
  • Bone marrow
  • Blood

Orthobiologic therapy involves the direct injection of these autologous or allogenic cellular components, such as platelets or subtances from bone marrow, adipose tissue, into the affected joint, ligament, tendon, or cartilage region. Upon administration, these biological agents potentially exert anti-inflammatory effects, facilitating pain relief, promoting tissue healing, and enhancing function and well-being. 

Orthobiologics present a promising alternative for individuals who are unsuitable candidates for surgical interventions or have sustained injuries that are refractory to conventional surgical repair. These therapies can be employed as standalone treatments or integrated into comprehensive treatment plans encompassing surgical procedures, physical therapy, or a combination thereof.

At Stanford Health Care, our team of esteemed clinicians and researchers are pioneers in the field of orthobiologics, having provided safe and efficacious regenerative medicine treatments for musculoskeletal injuries for over a decade. Our physicians and surgeons actively contribute to cutting-edge research endeavors aimed at expanding the applications of orthobiologics and optimizing patient outcomes following injury.

Our multidisciplinary team, comprising orthopedic surgeons, sports medicine specialists, and advanced practice providers, clinic coordinators is committed to guiding patients through a comprehensive evaluation of all available treatment options, ranging from minimally invasive therapies to surgical interventions.

To schedule an appointment for orthobiologics clinic, please call 650-723-5643. We recommend preparing relevant medical records, including current assessments, clinical notes, and previous imaging studies to facilitate a thorough evaluation during the appointment.

Our Team

Constance Chu, MD

Co-Director, Surgical Orthobiologics, Professor

Orthopaedic Surgery, Sports Medicine

Learn more about Dr. Chu

Eugene Y. Roh, MD

Co-Director, Non-Surgical Orthobiologics, Clinical Associate Professor

Physical Medicine and Rehabilitation, Sports Medicine

Learn more about Dr. Roh

Clinical Trials

Open trials refer to studies currently recruiting participants or that may recruit participants in the near future. Closed trials are not currently enrolling, but similar studies may open in the future.

Constance Chu, MD

Eugene Roh, MD